This protein is routinely shed by cells into the blood and is present in most body fluids, with highest levels in the blood, generally lower levels in spinal fluid , and trace levels in urine. 0000005920 00000 n 0000070538 00000 n 0000006268 00000 n Turnaround time is defined as the usual number of days from the date of pickup of a specimen for 0000093179 00000 n 0000002677 00000 n 0000063351 00000 n Beta-2-Microglobulin, Random Urine with Creatinine - Urinary Beta-2-Microglobulin is used as an indictor of renal impairment. 0000067329 00000 n xref Beta-2 microglobulin is a low-molecular-weight protein that forms the light chain component of class I histocompatibility (HLA: human leukocyte antigen) antigens. 0000009641 00000 n Intervals are Mayo-derived, unless otherwise designated. Describes reference intervals and additional information for interpretation of test results. Toxicol Lett 2003 Aug 28;143(3):279-290, 3. A beta-2 microglobulin test is usually a blood test, but may also be given as a 24-hour urine test, or as a cerebrospinal fluid (CSF) analysis. %%EOF Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf. 14 (17): 5341–7. 1 mL (Note: This volume does not allow for repeat testing.). Urine should always be collected at high diuresis and the pH adjusted to between 6 and 8 with 1 mol/L sodium hydroxide. 0000018236 00000 n trailer 0000008254 00000 n © 1995–2020 Mayo Foundation for Medical Education and Research. If beta 2 microglobulin is low in the blood and high in the urine, then it is likely that the person has proximal tubular renal damage or disease due to a variety of causes, including cadmium, mercury, lithium, or aminoglycoside toxicity; pyelonephritis; and Balkan … Provides information to assist in interpretation of the test results, Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances, Recommendations for in-depth reading of a clinical nature, Customized Instructions & Shipping Guides. 0000067762 00000 n Evaluate renal disease; monitor certain types of malignancies and AIDS. 0000052447 00000 n 0000000016 00000 n 0000070864 00000 n 0000071260 00000 n All Rights Reserved. testing to when the result is released to the ordering provider. 0000007736 00000 n Moriguchi J, Ezaki T, Tsukahara T, et al: Comparative evaluation of four urinary tubular dysfunction markers, with special references to the effects of aging and correction for creatinine concentration. 0000093877 00000 n Suggests clinical disorders or settings where the test may be helpful, Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test. 0000013570 00000 n Beta-2 microglobulin (B2M) is a protein that is found on the surface of nucleated cells (contain a nucleus) and functions as part of the human immune system. LabCorp and its Specialty Testing Group, a fully integrated portfolio of specialty and esoteric testing laboratories. Beta-2 microglobulin is a low-molecular-weight protein that forms the light chain component of class I histocompatibility (HLA: human leukocyte antigen) antigens. 0000038061 00000 n 0000001345 00000 n 0000063262 00000 n Patient should empty the bladder, then drink a large glass of water and collect a urine sample within one hour. h�b```b``[�����|�A�X��,[���/a�K�. Walk-ins are also welcome. 0000023081 00000 n © 2020 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved. "Beta2-microglobulin signaling blockade inhibited androgen receptor axis and caused apoptosis in human prostate cancer cells". ����G/���,A 0000001926 00000 n Significant loss of β 2 -microglobulin activity may occur in acidic urine (pH ≤6). 0000003978 00000 n 1212 51 %PDF-1.4 %���� Toxicol Lett 2003 Feb 3;137(3):135-141, 2. Beta-2-Microglobulin, Urine - Beta-2-Microglobulin (B2M) is a low molecular weight protein that forms the light chain component of the histocompatibility antigen. It is an integral part of the class I MHC antigens and is present in all body fluids. 0000030391 00000 n In some cases, additional time should be 0000009152 00000 n 0000004833 00000 n 0000003143 00000 n B2M is filtered through the glomeruli of the kidney and is then reabsorbed and catabolised by the proximal tubular cells. (September 2008). endstream endobj 1261 0 obj <>/Filter/FlateDecode/Index[92 1120]/Length 52/Size 1212/Type/XRef/W[1 1 1]>>stream ���>M(��p肫/P���0����&��B"4vtt000[0�@ZZGH�����2� �'K�| ���`}~�_@mlx�2�`�d�`-a�`Q�hrd������B����T'kc���uKV��_�牬��fcX��������\+��X�V7�*z�w]nbhb;���W_�\y ���� ����#. PMC 3032570. Serum and plasma beta 2 microglobulin values have emerged as markers for the activation of the cellular immune system, as well as a tumor marker in certain hematologic malignancies. It is synthesized by all nucleated cell types. 0000066976 00000 n 1212 0 obj <> endobj startxref 0000093436 00000 n Urine should always be collected at high diuresis and the pH adjusted to between 6 and 8 with 1 mol/L sodium hydroxide. © 2020 Laboratory Corporation of America® Holdings. Ikeda M, Ezaki T, Tsukahara T, et al: Threshold levels of urinary cadmium in relation to increases in urinary beta2-microglobulin among general Japanese populations. All Rights Reserved. h���A 0ð4�q\Gc���������z�C. 0000103682 00000 n After the needle is inserted, a small amount of blood will be collected into a test tube or vial. Testing schedules may vary. 1262 0 obj <>stream
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