2012 Feb 1. Efficacy of granulocyte and granulocyte-macrophage colony-stimulating factors in the induction treatment of adult acute lymphoblastic leukemia: a multicenter randomized study. J Clin Oncol. The GIMEMA ALL 0183 trial: analysis of 10-year follow-up. 2013 Nov 7. In 2012, the American Society for Blood and Marrow Transplantation (ASBMT) updated its treatment recommendations for SCT in adults with ALL, based on new evidence. Pediatric-inspired therapy compared to allografting for Philadelphia chromosome-negative adult ALL in first complete remission. The challenge of access to care for soft tissue sarcomas bridging pediatric and adult age: the Italian pediatric oncology view. 91 (3):322-9. [20], In 2017, the College of American Pathologists and the American Society of Hematology (CAP/ASH) issued guidelines on the initial diagnostic workup of acute leukemia (AL). Comparison of the Results of the Treatment of Adolescents and Young Adults With Standard-Risk Acute Lymphoblastic Leukemia With the Programa Español de Tratamiento en Hematología Pediatric-Based Protocol ALL-96. : Ariad Pharmaceuticals, Inc. December 2013. [20] : For optimal risk stratification and treatment planning in patients with ALL, the NCCN advises that bone marrow or peripheral blood lymphoblasts must be tested for specific recurrent genetic abnormalities, as follows Genomic analysis of adult B-ALL identifies potential markers of shorter survival. Ann N Y Acad Sci 2014; 1329:81. In this retrospective study, we aimed to evaluate the safety, tolerability and efficacy of MASPORE protocol in relation to the standard adult ALL protocol - HyperCVAD in young adult aged 18-30 years who were diagnosed with Philadelphia-negative (Ph-) ALL. 2011 Nov;96(11):1627-35. doi: 10.3324/haematol.2011.047993. From day 29 the dose of dexamethasone is reducing: days 29-30 - 3 mg/m2, days 31-32 - 1.5 mg/m2, then dexamethasone is discontinued completely. [Medline]. Symptom Interval and Patient Delay Affect Survival Outcomes in Adolescent Cancer Patients. Arch Pathol Lab Med. Harrison CJ, Moorman AV, Schwab C, et al. Median Leukemia Free Survival (LFS) in MASPORE was not reached. Blood. 2010 Aug 1. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Pediatric Blood Cancer 2006;47:748–756. 2001 Sep. 114 (3):539-43. Nat Rev Cancer. 2016 Dec 1. [Medline]. Talk with your doctor and family members or friends about deciding to join a study. 1998 May. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. Please check your email for instructions on resetting your password. Pichler H, Möricke A, Mann G, Teigler-Schlegel A, Niggli F, Nebral K, König M, Inthal A, Krehan D, Dworzak MN, Janousek D, Harbott J, Schrappe M, Gadner H, Strehl S, Haas OA, Panzer-Grümayer R, Attarbaschi A; Berlin-Frankfurt-Münster (BFM) Study Group. 2007. From day 29 the dose of dexamethasone is reducing: days 29-31 - 3 mg/m2, days 32-34 - 1.5 mg/m2, days 35-36 - 0.75 mg/m2; then dexamethasone is discontinued completely. For pediatric patients with suspected or confirmed B-ALL, ensure testing for t(12;21)(p13.2;q22.1); ETV6-RUNX1, t(9;22)(q34.1;q11.2); BCR-ABL1, KMT2A (previously MLL) translocation; iAMP21; and trisomy 4 and 10 is performed. Maintenance therapy: 6 mg/m2, per os, in two divided doses per day q12 hours, for 10 days followed by quick discontinuation during 3 days. [Medline]. Liu Y, Easton J, Shao Y, et al. The National Comprehensive Cancer Network (NCCN) provides frequently updated recommendations for the diagnosis and management of acute lymphoblastic leukemia (ALL), along with surveillance milestones or algorithms to monitor response to treatment. [Medline]. 1-28 day (dose in the first few days is depending on the total tumor mass). . Based on patterns of referral, they may be treated by either paediatric or adult oncologists. Consolidation: 8 mg/m2, intravenously, for 6 hours on days 44, 65 (consolidation S1); 107, 121 (consolidation S2); and 163 (consolidation S3). 102(7):2379-86. Hematology Am Soc Hematol Educ Program. Blood. 2006661-overview Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies. Induction therapy with continuous Dexamethasone administration (6 mg/m2 1-29 days). Kantarjian H, Giles F, Wunderle L, Bhalla K, O'Brien S, Wassmann B, et al. [Medline]. [Full Text]. Adolescents with acute lymphoblastic leukemia treated at pediatric versus adult hospitals. Shalapour S, Hof J, Kirschner-Schwabe R, Bastian L, Eckert C, Prada J, Henze G, von Stackelberg A, Seeger K. Haematologica. Weiss M, Maslak P, Feldman E, Berman E, Bertino J, Gee T, et al. 1987. 2005 Dec 1. 2. [Medline]. Childhood acute lymphoblastic leukemia (ALL) treatment is usually chemotherapy given in phases and determined by risk group. [Medline]. 2012 Jul;97(7):1048-56. doi: 10.3324/haematol.2011.047613. 2013 Sep 20. Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia. Blood. Median OS in MASPORE was not reached. 23(15):3396-403. Allo for Everyone. Induction: 6 mg/m2, per os, in two divided doses per day q12 hours. Time to Stop Pressuring Women on Screening Mammography? Myths and Lessons from the Adult/Pediatric Interface in Acute Lymphoblastic Leukemia. What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? Treatment of adult acute lymphoblastic leukemia with intensive cyclical chemotherapy: a follow-up report. 11 patients in MASPORE group had at least 1 episode of grade 3 or more transaminitis, compared to 3 patients in HyperCVAD. Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group. 35 (1):130-134. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. The flow cytometry panel should be sufficient to distinguish acute myeloid leukemia (including acute promyelocytic leukemia), T-ALL (including early T-cell precursor leukemias), B-cell precursor ALL (BCP-ALL), and AL of ambiguous lineage for all patients diagnosed with AL. Bone Marrow Transplant. [Medline]. Hematol Oncol. Rowe JM, Buck G, Burnett AK, Chopra R, Wiernik PH, Richards SM, et al.
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